Levonorgestrel is rapidly absorbed. Levonorgestrel have no effect “first pass” through the liver. The half-life of 8-30 hours (mean 16 hours). Most of levonorgestrel in blood binds to albumin and globulin, sex hormone binding.
Ethinyl estradiol is rapidly and almost completely absorbed from the gastrointestinal tract. Maximum plasma concentration is achieved in the range of 1-1.5 hours. Ethinylestradiol inherent effect of “first pass” through the liver (the so-called “first pass” effect). Metabolism in the liver and intestine.
When administered ethinyl estradiol released over 12 hours from the blood plasma.
Metabolites ethinylestradiol: water soluble sulfate proviron for women or glucuronide derivatives conjugation enter the intestine with bile, where they are subjected to disintegration using intestinal bacteria. 60% of levonorgestrel excreted by the kidneys, 40% – through the intestine, 40% ethinylestradiol excreted by the kidneys and 60% – through the intestines.
Hypersensitivity to any component of the drug.
Pregnancy, lactation, severe liver disease, liver tumors, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), cholelithiasis, cholecystitis, chronic colitis; the presence or indication of a history of severe cardiovascular (including decompensated heart defects) and cerebrovascular changes, thromboembolism and predisposition to them, phlebitis deep veins of the lower extremities, hormone-dependent malignancies genitals and mammary glands (including suspicion on them), familial forms of hyperlipidemia, hypertension with systolic / diastolic blood pressure of 160/100 mm Hg and above, surgery, surgery on the lower extremities, prolonged immobilization, major trauma, pancreatitis (including history), accompanied by severe hypertriglyceridemia, and hyperlipidemia, jaundice due to proviron for women medication containing steroids, severe diabetes, sickle cell anemia, chronic hemolytic anemia, vaginal bleeding of unknown etiology, migraines, molar pregnancy, otosclerosis with deterioration during the course of the previous (their) pregnancy (children); pregnant women idiopathic jaundice, severe itching during pregnancy, herpes gestationis in history; smoking at the age of 35 years, age greater than 40 years; lactase deficiency, lactose intolerance, glucose-galactose malabsorption (lactose contained in the dosage form of the drug).
compensated diabetes without vascular complications, hypertension with systolic / diastolic blood pressure up to 160/100 mm Hg, varicose disease, multiple sclerosis, epilepsy, chorea, porphyria, tetany, asthma, adolescence (without regular ovulatory cycles), uterine fibroids, breast disease, depression, tuberculosis.
Pregnancy and lactation
During pregnancy and lactation the drug proviron for women is contraindicated.
DOSAGE AND ADMINISTRATION The use of the preparation for the first time: . Ingest, at the same time of the day, possibly at night, without chewing, and with a small amount of liquid for contraception in the first cycle administered daily 1 tablet /. d. within 21 days, starting on day 1 of the menstrual cycle, then make a 7-day break, during which there comes a typical menstrual bleeding.Admission next pack containing 21 film-coated tablets, it is necessary to start on the 8th day after the 7-day break. The drug is carried out as long as there is a need for contraception. When switching from another oral contraceptive applied a similar scheme. after the abortion drug reception is recommended to start on the same or next day after surgery. after birth, the reception of the drug is recommended only for women not breastfeeding. The reception should begin no earlier than the first day of menstruation cycle. during lactation the use of the drug is contraindicated. If a woman did not accept proviron for women in due time, should take the missed pill during the next 12 hours. If after taking the tablets have passed 36 hours contraception can not be considered reliable. However, in order to avoid inter-menstrual bleeding should continue taking the drug have already started packing of net missed (ones) tablet (s). At this time, it is recommended to additionally use other, non-hormonal contraceptive method (e.g., a barrier).